Background: Infantile SLE is an extremely rare disease as underlined by the fact that there are only few publications in the literature (only 13 patients have been published until now).

Objectives: Case report of a rare disease.

Methods: We report on a female patient who developed infantile systemic lupus erythematosus (iSLE) during the first year of life. At the age of 8 months the child presented with dry cough, strained breathing and agitation at night. 2 months later she developed fever attacks and a skin rash localized on the cheeks in a butterfly shape as well as on the extremities.

Based on the clinical symptoms, serological findings and the skin biopsy we diagnosed infantile systemic lupus erythematosus.

Results: Because the skin rash was unresponsive to steroid therapy, we decided to start a systemic treatment with hydroxychloroquine which dramatically improved the skin symptoms and fever attacks. Since the beginning of the therapy the patient has not yet developed a relapse of disease or any other systemic symptoms.

Conclusions: In conclusion, we present a rare case of infantile systemic lupus erythematosus. To our best knowledge we are the first to describe a successful treatment with systemic hydroxychloroquine in a patient with iSLE. Since the induced therapy with hydroxychloroquine the patient did not suffer from skin rash or other systemic symptoms any more.

Disclosure of Interest: None declared

DOI: 10.1136/annrheumdis-2015-eular.4482