OP0120 (2018)
Influence of epidemiology and ethnicity on systemic expression of primary sjÖgren syndrome in 9974 patients
S Retamozo1,2,3, N. Acar-Denizli4, W. Fai Ng5, M. Zeher6, A. Rasmussen7, R. Seror8, X. Li9, C. Baldini10, J.-E. Gottenberg11, D. Danda12, L. Quartuccio13, R. Priori14, G. Hernandez-Molina15, B. Armagan16, A.A. Kruize17, S.-K. Kwok18, M. Wahren-Herlenius19, S. Praprotnik20, D. Sene21, E. Bartoloni22, R. Solans23, M. Rischmueller24, T. Mandl25, Y. Suzuki26, D. Isenberg27, V. Valim28, P. Wiland29, G. Nordmark30, G. Fraile31, H. Bootsma32, T. Nakamura33, R. Giacomelli34, V. Devauchelle-Pensec35, B. Hofauer36, M. Bombardieri37, V. Fernandes Moça Trevisani38, D. Hammenfors39, S.G. Pasoto40, T.A. Gheita41, F. Atzeni42, J. Morel43, C. Vollenveider44, P. Brito-Zerón45, M. Ramos-Casals1,45,1, on behalf of the Sjogren Big Data Consortium
1H. Clinic, IDIBAPS, Barcelona, Spain
2H. Privado Cordoba, IUCBC
3INICSA, UNC-CONICET, Cordoba, Argentina
4Mimar Sinan Univ, Istanbul, Turkey
5Newcastle Univ, NHS Foundation Trust, Newcastle, UK
6Debrecen Univ, Debrecen, Hungary
7Oklahoma Medical Research Foundation, Oklahoma, USA
8Université Paris Sud, INSERM, Paris, France
9Anhui Provincial Hosp, Hefei, China
10Pisa Univ, Pisa, Italy
11Strasbourg Univ, CNRS, Strasbourg, France
12Christian Medical College and Hosp, Vellore, India
13Hosp ‘Santa Maria della Misericordia’, Udine
14Sapienza Univ, Rome, Italy
15INCMNSS, México City, Mexico
16Hacettepe Univ, Ankara, Turkey
17Univ Medical Center, Utrecht, Netherlands
18Catholic Univ of Korea, Seoul, Korea, Republic Of
19Karolinska Institute, Stockholm, Sweden
20Univ Medical Centre, Ljubljana, Slovenia
21Univ Paris VII Publique-Hôpitaux de Paris, 2, Paris, France
22Perugia Univ, Perugia, Italy
23H. Vall d’Hebron, Barcelona, Spain
24Western Australia Univ, Crawley, Australia
25Malmö Hosp, Lund Univ, Lund, Sweden
26Kanazawa Univ Hosp, Ishikawa, Japan
27University College, London, UK
28Federal Univ Espírito Santo, Vitória, Brazil
29Wroclaw Medical Hospital, Wroclaw, Poland
30Uppsala Univ, Uppsala, Sweden
31H. Ramón y Cajal, Madrid, Spain
32Univ Medical Center, Groningen, Netherlands
33Nagasaki University, Nagasaki, Japan
34L’Aquila Univ, L’Aquila, Italy
35Brest Univ Hosp, CERAINO, Brest, France
36Technische Univ, Munchen, Germany
37Queen Mary Univ, London, USA
38Federal Univ São Paulo, Sao Paulo, Brazil
39Haukeland Univ Hosp, Bergen, Norway
40Hospital das Clínicas, USP, São Paulo, Brazil
41Cairo University, Cairo, Egypt
42Messina and Milan Univ, Milan, Italy
43Hosp and Univ of Montpellier, Montpellier, France
44German Hosp, Buenos Aires, Argentina
45H. CIMA- Sanitas, Barcelona, Spain
Objectives: To analyse the influence of epidemiology and ethnicity on the clinical systemic presentation at diagnosis of primary Sjögren syndrome (SjS).
Methods: The Big Data Sjögren Database included 10 475 worldwide patients from 22 countries fulfilling the 2002 criteria. Age at diagnosis, gender and ethnicity (77% White, 14% Asian, 6% Hispanic, 1% Black/African American, 2% others) were correlated with systemic involvement at diagnosis (retrospectively scored in 9974 patients using ESSDAI/clinESSDAI)
Results: Men had higher mean ESSDAI (8.0 vs 5.9, p<0.001) and clinESSDAI (8.4 vs 6.1, p<0.001) in comparison with women; the domains more active in men included lymphadenopathy (p<0.001), glandular (p<0.001), pulmonary (p=0.001), PNS (p<0.001) and CNS (p<0.001). Highest scores were also reported in patients with young-onset disease (<35 years) with respect to older onset (>65 years) for ESSDAI (6.5 vs 5.6, p=0.002) and clinESSDAI (6.4 vs 5.8, p=0.034). Highest ESSDAI scores were reported in Black/African American, followed by White, Asian and Hispanic patients (6.7 vs 6.3 vs 5.4 vs 4.9, respectively, p<0.001). BAA patients showed the highest frequency of activity in lymphadenopathy, articular, PNS, CNS and biological domains, Whites in glandular, cutaneous and muscular, Asians in pulmonary, renal and haematological and Hispanics in the constitutional domain.
Conclusions: This study provides the first evidence for a strong influence of epidemiology and ethnicity on the systemic phenotype at diagnosis of primary SjS
Disclosure of Interest: None declared
DOI: 10.1136/annrheumdis-2018-eular.6073
Citation: Ann Rheum Dis, volume 77, supplement Suppl, year 2018, page A110
Session: SLE, Sjögren’s and APS- new criteria, novel diagnostic tools and co-morbidities
