Background: It is assumed that the risk of developing diabetes mellitus (DM) is due not only to generally accepted risk factors (RF), but also to RF related to gout.

Objectives: To evaluate the influence of various RF for DM in pts with gout.

Methods: 444 pts aged ≥18 years with a crystal-verified diagnosis of gout without DM were included in the study. The average duration of observation was 5.66 [2.69; 7.4] yrs. To identify the RF associated with developing of DM in patients with gout, multivariate logistic regression was used. There were included: gender; DM in relatives; insufficient physical activity; unbalanced diet; age ≥45 yrs; ≥ 4 exacerbation of arthritis per yr; presence of tophi; BMI ≥ 30 kg/m ² ; presence of hypertension; allopurinol, febuxostat, GC, diuretics, metformin or colchicine intake; GFR <60 ml/min/1.73 m ² ; serum uric acid (sUA) level ≥420 µmol/l; UA ≥480 µmol/l. Statistica 12.0 package was used for statistical data processing.

Results: DM was developed in 108 (24.3%) pts. Pts who developed DM were older than those who did not develop (52.84±10.96 vs 49.72±11.95 respectively, p=0.02); they were more likely to have heredity for DM of the first and second kinship lines (49.1% vs 25.6% respectively, p=0.0001); they took antihypertensive drugs more often (73.1% vs 50.5%, p=0.0001), also diuretics (27.7% vs 14.8%, p =0.003) and GC (47.2% vs 36.4%, p=0.047). There were more pts with subcutaneous tophi (59.3% vs 29.9%, p=0.001), those who had ≥ 4 attacks of arthritis per yr (67.6% vs 31.6%, p=0.001), sUA ≥480 µmol/l (71.3% vs 50.8%, p=0.0002), sUA≥600 µmol/l (34.3% vs 11.8%, p=0.0002).

According to a multivariable logistic regression, the risk of DM is increased in case of: ≥ 4 arthritis attacks per yr (odds ratio [OR] 5.231, 95% confidence interval [CI] 2.978-9.187, p=0.0001); presence of subcutaneous tophi (OR 2.609, 95% CI 1.500-4.537, p=0.001); sUA level ≥480 µmol/l (OR 2.261, 95% CI 1.022-5.004, p=0.144); hypertension (OR 2.577, 95% CI 1.348-4.926, p=0.004); taking diuretics (OR 2.353, 95% CI 1.193-4.64, p=0.014). The risk of developing DM was reduced by taking febuxostat (OR 0.309, 95% CI 0.113-0.844, p=0.022) and metformin (OR 0.49 (95% CI 0.21; 1.16), p=0.107).

Conclusion: The risk of developing DM in pts with gout is associated with the frequency of arthritis attacks, sUA level ≥480 µmol/l, hypertension and diuretics intake. Therapy with febuxostat or metformin is associated with descended risk of DM.

Disclosure of Interests: Olga Sheliabina Speakers bureau: Berlin Chemie Menarini Group, Maxim Eliseev Speakers bureau: Berlin Chemie Menarini Group, Sobi, EGIS, CSC, MosFarma, Alium Group, Svetlana Glukhova: None declared