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Background: Nowadays, the COVID-19 and its complications are considered an important medical issue with aggravated medico-social outcomes, both at the worldwide scale, and in terms of various individual countries. Despite the recent ASBMR, AACE, Endocrine Society, ECTS and NOF recommendations according to osteoporosis management in the era of COVID-19 the influence of antiosteoporotic drugs on disease incidence and severity continue to be studied [1, 2].
Objectives: The purpose of this study was to assess the COVID-19 risk for the patients receiving the parenteral bisphosphonate or Denosumab treatment, and the severity of its course in the systemic osteoporosis patients.
Methods: We performed the phone survey and studied the results of 195 patients (92 % women; mean age – 62.7±10.8 years, height – 161.0±8.0 cm, body weight – 68.9±12.3 kg) with systemic osteoporosis depending on the current use of parenteral antiresorptive drugs (Zoledronic acid, Ibandronic acid, or Denosumab, n=125) and compared the results with patients with osteoporosis who did not use any antiosteoporotic drugs previously (n=70). The mean duration of antiosteoporotic treatment did not vary across the groups, accounting for 15 [9-27] months. Prior to the beginning of the antiosteoporotic therapy, all the patients had a confirmed diagnosis of osteoporosis at the Ukrainian scientific-medical Center of osteoporosis.
Results: We did not reveal any significant differences in the COVID-19 frequency and severity depending on the presence and type of parenteral antiosteoporotic therapy. Additionally, there were no differences depending on patients’ age of sex, obesity presence, and other osteoporosis risk factors. The risk of COVID-19 in the patients with systemic osteoporosis did not differ depending on antiresorptive drug use, amounting (Odd Ratio (OR) 95 % CI) to 1.1 (0.6-2.0), or on the use of the definite antiosteoporotic drug (for the Zoledronic acid - 0.9 (0.4-2.0), the Ibandronic acid - 1.1 (0.5-2.3), and for the Denosumab - 1.6 (0.5-5.2).
Conclusion: Our study did not reveal any significant differences in the COVID-19 frequency and severity depending on the presence and type of parenteral antiosteoporotic therapy. We conclude that parenteral antiosteoporotic drugs (Zoledronic acid, Ibandronic acid, or Denosumab) do not have an influence on COVID-19 frequency and severity and can be recommended for the continuation of treatment of patients with osteoporosis.
REFERENCES:
[1]Joint Guidance on Osteoporosis Management in the Era of COVID-19 from the ASBMR, AACE, Endocrine Society, ECTS & NOF.
[2]Blanch-Rubió J, Soldevila-Domenech N, Tío L, et al (2020) Influence of anti-osteoporosis treatments on the incidence of COVID-19 in patients with non-inflammatory rheumatic conditions. Aging (Albany NY). 12(20):19923-19937. doi:10.18632/aging.104117.
Disclosure of Interests: None declared