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Background: One of the most common comorbid conditions accompanying rheumatoid arthritis is atherosclerosis and arterial hypertension. Previous studies have shown a change in the blood lipid spectrum with an increase in the atherogenic index in children with juvenile idiopathic arthritis. The next link in the development of this pathology is a change in the endothelial function of the vessels.
Objectives: To study the level of angiotensin-converting enzyme in children with JIA and establish its interdependence with the blood lipid spectrum of sick children.
Methods: The level of angiotensin-converting enzyme (ACE) was studied in 46 children (28 girls and 18 boys) from 11 to 17 years old by enzyme immunoassay as well as indicators of the lipid spectrum: low density lipoprotein cholesterol (LDL), very low-density lipoprotein cholesterol (VLDL) and atherogenic coefficient. The results obtained were compared with the data of children in the control group, which consisted of 34 people. Data were analyzed depending on patients’ gender, age, and age of JIA onset, its variant, duration, activity, and presence of methotrexate (MTX).
Results: The results of the study are presented in the
| Lipid spectrum indicators | Children’s groups | M+m | Me | Min | Max | р |
|---|---|---|---|---|---|---|
| LDL | JIA, n=46 | 2,33±0,09 | 2,18 | 0,97 | 4,31 | 0,001 |
| Control, n=34 | 2,5±0,09 | 2,55 | 1,39 | 4,13 | ||
| VLDL | JIA, n=46 | 0,36±0,09 | 0,35 | 0,13 | 1,1 | 0,001 |
| Control, n=34 | 0,14±0,01 | 0,13 | 0,06 | 0,27 | ||
| KA | JIA, n=46 | 2,04±0,09 | 1,83 | 0,82 | 3,5 | 0,4 |
| Control, n=34 | 2,03±0,09 | 2,02 | 0,83 | 3,8 | ||
| ACE | JIA, n=46 | 41,23±3,9 | 35,59 | 14,4 | 101,2 | 0,2 |
| Control, n=34 | 40,22±6,37 | 46,75 | 17,97 | 63,78 |
There were no significant differences in the ACE level in children with JIA in comparison with the control group. Analysis of the data obtained did not reveal significant changes in the obtained ACE parameters depending on the gender and age of patients, JIA activity, and the presence of MTX in complex treatment. At the same time, a direct correlation of ACE values and low-density lipoprotein levels (r=0.5, p<0.05) was obtained, which confirms the relationship between the ACE level and the development of dyslipoproteinemia in children with JIA.
Conclusion: The obtained results illustrate the stages of development of atherogenic changes in children with JIA. Data were obtained that against the background of an increase in the level of VLDL and a decrease in LDL, the level of ACE remains preserved, which reflects the absence of changes in the endothelium. Research into these changes is ongoing.
Disclosure of Interests: None declared