Background: Systemic Lupus Erythematosus (SLE) patients have a 3- fold risk of CV events compared to the general population, mainly due to accelerated atherosclerosis that is not completely explained by the presence of traditional CV risk factors. Individuals with increased Intimal medial thickness (IMT) carry a higher risk to develop carotid atherosclerosis. Accordingly, IMT acts as a marker of subclinical atherosclerosis. In recent studies, SLE patients showed a significant higher IMT compared to healthy subjects. On the other side, SLE retinal involvement can be detected in 7-29% of cases, it is characterized mainly by retinal vasculopathy and it can be a marker of systemic vascular involvement. Optical Coherence Tomography Angiography (OCTA), a new diagnostic technique that can visualize retinal blood flow and evaluate the Fovea Avascular Zone (FAZ), has been investigated as an instrument for early detection of subclinical retinal vascular impairment in SLE.

Objectives: Aim of this study is to examine a possible correlation between IMT and retinal vascular impairment assessed through OCTA in SLE.

Methods: We recruited SLE patients fulfilling 2019 EULAR/ACR classification criteria. Patients with other rheumatic, ophthalmological diseases, diabetes or history of CV diseases were excluded. We also collected patients’ demographic and clinical data, including sex, age, smoking habit, BMI, systolic and diastolic blood pressure (BP), C-Reactive Protein (CRP), total cholesterol, LDL, HDL, triglycerides. All patients underwent an ophthalmological evaluation, including OCTA estimation of superficial and deep retinal vessel density (VD), considering both the whole image and the foveal region, and FAZ area. Carotid ultrasound (US) comprising IMT assessment was also performed. Statistical analysis was accomplished using unpaired t-test or Mann Whitney U test, Pearson or Spearman rank correlation when appropriate.

Results: We enrolled 37 SLE patients; demographic, clinical and US data are displayed in Table 1 . Nine patients (24.3%) had uncontrolled arterial hypertension. According to US evaluation, carotid plaques were detected in six patients (16.2%). OCTA data were correlated with IMT values showing a negative correlation between IMT and both superficial and deep fovea VD (p=0.003, r=-0.4 and p=0.004, r=-0.4), while a positive correlation was found with FAZ area (p=0.02, r=0.4).

IMT positively correlated with traditional CV risk factors, particularly age (p<0.0001, r=0.7), BMI (p=0.007, r=0.3) and systolic BP (p=0.001, r=0.4). Patients with high BP levels showed not only a significant higher IMT compared to the group with normal BP values (p=0.04), but also a significant increased FAZ area (p=0.02). FAZ area correlated positively with CRP levels (p=0.0001, r=0.5). Triglycerides showed a positive correlation with IMT values (p=0.001, r=0.4) and FAZ area (p=0.04, r=0.3) while correlated negatively with deep fovea VD (p=0.04, R=-0.4). A reduction in deep whole retinal VD was detected among patients with carotid plaques compared to the group without (p=0.02), together with higher IMT values (p=0.04).

Conclusion: Retinal vascular impairment in SLE has been associated with IMT, atherosclerotic plaques and some CV risk factors as hypertension, hypertriglyceridemia and CRP levels. Search for new markers of preclinical CV damage in SLE is currently ongoing and OCTA might be an additional instrument to assess preclinical cardiovascular involvement in SLE.

Disclosure of Interests: None declared