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AB1027 (2023)
CHARACTERISTICS OF UVEITIS IN SPONDYLOARTHRITIS IN A MULTICENTER STUDY IN MOROCCO
H. Arabi1, A. Mougui1, H. Sahimi2, N. Takhrifa3, S. Mouhcine4, T. Harzy2, F. Abourazzak3, S. Janani4, R. Bahiri5, A. Bezza6, I. El Ghozlani7, R. Niamane8, I. El Bouchti1
1Centre Hospitalo-Universitaire Mohammed VI Marrakech, Department of Rheumatology, Marrakech, Morocco, Rheumatology, Marrakesh, Morocco
2Hospital Fes, Rheumatology, Fes, Morocco, Rheumatology, Fes, Morocco
3Mohammed V Hospital Tanger, Rheumatology, Tanger, Morocco, Rheumatology, Tangier, Morocco
4Ibn Rochd University Hospital Casablanca, Rheumatology, Casablanca, Morocco, Rheumatology, Casablanca, Morocco
5El Ayachi Hospital, Ibn Sina University Hosiptal Salé-Rabat, Rheumatology, Salé-Rabat, Morocco, Rheumatology, Salé-Rabat, Morocco
6Military Hospital Mohammed V Rabat, Rheumatology, Rabat, Morocco, Rheumatology, Rabat, Morocco
7Military Hospital Agadir, Rheumatology, Marrakech, Morocco, Rheumatology, Agadir, Morocco
88 Military Hospital Avicenne Marrakech, Rheumatology, Marrakesh, Morocco

 

Background Uveitis is the most common extra-articular manifestation of Spondyloarthritis (SpA).

Objectives The aim of this study was to determine the prevalence of uveitis in patients with SpA in a multicenter series and to identify factors associated with its occurrence.

Methods A multicenter descriptive analytical study, including patients followed for SpA in 8 rheumatology departments from 6 different regions in Morocco. All data were measured by standard instruments. Demographic, clinical, paraclinical and therapeutic data of the disease were collected. Disease activity was assessed by BASDAI and ASDAS-CRP scores. Data analysis was done by SPSS.20 software, the p significance level was set at 0.05.

Results The study had included 700 patients followed for SpA, 54% of whom were men. The mean age at diagnosis was 40.42 + 14.19 years. The average diagnosis delay was 59.76 months. The percentage of patients who smoked was 15.6%. A family history of SpA was noted in 11.7%. SpA was non-radiographic in 14% of cases. Bilateral sacroiliitis was described in 49.4%. Coxitis was present in 32.5%. Juvenile SpA represented 15.5% of cases. The prevalence of HLA-B27 was 65.51%. Systemic involvement was dominated by uveitis (11.3%), it was unilateral in 59.5%, bilateral in 28.6% and tilted in 11.9%, anterior in 95.7%. Evolution of the uveitis was acute in 88.9% and chronic in 11.1%. The mean of BASDAI and ASDAS ware 4.42 ±1.67 and 3.19 ±1.24 respectively. The mean CRP and erythrocyte sedimentation rate (ESR) were 35.5 mg/l and 43.3mm respectively.

The mean BASDAI was significantly higher in SpA with uveitis (p=0.025). Biological treatments, in particular tumor necrosis factor-α (TNF-α) inhibitors were more prescribed in patients with uveitis; 47.5% versus 30.9% in SpA without uveitis, with a significant difference (p=0.006). Uveitis was less present in SpA associated with inflammatory bowel disease (p=0.004). However, we did not find a significant association with gender (p=0.61), age at diagnosis (p=0.69), age of onset of symptoms (p=0.8), diagnostic delay (p=0, 58), smoking (p=0.06), clinical forms of SpA (p=0.71), coxitis (p=0.6), HLA B27 antigen (p=0.17), ESR (p=0.56), CRP (p=0.99) and ASDAS-CRP (p=0.51).

Conclusion In our study, the prevalence of uveitis was 11.3%. Its presence was associated with a higher activity according to the BASDAI, and it was associated with a higher use of biological treatments.

Reference [1]Rademacher J, Poddubnyy D, Pleyer U. Uveitis in spondyloarthritis. Therapeutic Advances in Musculoskeletal. 2020 Jan;12:1759720X2095173.

Acknowledgements: NIL.

Disclosure of Interests None Declared.

Keywords: Uveitis, Spondyloarthritis

DOI: 10.1136/annrheumdis-2023-eular.5838

Citation: , volume 82, supplement 1, year 2023, page 1736
Session: Spondyloarthritis - clinical aspects (other than treatment) (Publication only)