Background: Autoimmune Rheumatic Diseases (ARDs encompasses conditions like rheumatoid arthritis and lupus, have systemic impacts altering physiological responses. During pregnancy, ARDs pose additional risks, particularly in relation to postpartum haemorrhage (PPH), a leading cause of maternal death. This research delves into the connection between ARDs and PPH, aiming to identify variations in outcomes within this disease group.

Objectives: To explore postpartum hemorrhage (PPH) outcomes in individuals with and without ARDs in terms of transfusion, acute anemia, length of stay, total hospitalisation charges

Methods: The Nationwide Inpatient Sample database from 2015 to 2019 was utilized, and patients with principal ICD-10 diagnosis code of Post-Partum Hemorrhage. Secondary Diagnosis was used to incorporate variables which are associated with Postpartum Hemorrhage. The information was used with the most recent Health Care Utilization Project guidelines, employing weighted data for subsequent analysis. Univariate analysis utilized student’s t-test and chi-square, after that a multi variate regression model was built. This model was adjusted for hospital-level confounders and diverse co-morbidities, generating odds ratios. Significance was established at a P-value <0.05. The entire analysis was conducted using STATA-MP v14.2.

Results: For blood transfusion, both univariate (OR=0.91, 95% CI: 0.39-2.11, p=0.832) and multivariate (adjusted OR=0.92, 95% CI: 0.40-2.13, p=0.0857) show no significant associations. acute anemia exhibits non-significant findings in both univariate (OR=1.23, 95% CI: 0.64-2.37, p=0.520) and multivariate (adjusted OR=1.25, 95% CI: 0.65-2.39, p=0.488). Length of stay (LOS) lacks significance in both univariate (coefficient=-0.19, 95% CI: -0.36 to -0.32, p=0.911) and multivariate (adjusted coefficient=-014, 95% CI: -0.364 to 0.33, p=0.937). Total charges (TOT CHG) demonstrate non-significant results in univariate (mean diff=$324, 95% CI: -$5648 to -$6298, p=0.915) and multivariate (adjusted mean diff=$668, p=0.818).

Conclusion: The current study provides a framework for future research on the complex relationship between ARDs and PPH outcomes. Our findings suggest similar outcomes for patients with and without ARDs, but these conditions are complex and require ongoing research to understand their effects on maternal health. To better understand the relationship between ARDs and PPH, further investigation into disease-specific factors and complex relationships is needed.

REFERENCES: [1] Yasmeen S, Wilkins EE, Field NT, Sheikh RA, Gilbert WM. Pregnancy outcomes in women with systemic lupus erythematosus. J Matern Fetal Med. 2001 Apr;10(2):91-6. DOI: 10.1080/714904302. PMID: 11392599.

Acknowledgements: NIL.

Disclosure of Interests: None declared.