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POS1417 (2025)
RHEUMATOID ARTHRITIS AND INTERSTITIAL LUNG DISEASE IN HOSPITALIZED PATIENTS: A FIVE-YEAR NATIONWIDE ANALYSIS
Keywords: Autoantibodies, Lungs, Epidemiology, Quality of life, Diversity, Equity, And Inclusion (DEI)
T. V. Mohta1, U. Chukwuemeka1, P. Barve1, B. Khin1, S. Vuong1, P. Tangirala1, M. Baidya1
1Hemet Global Medical Center, Hemet, United States of America

Background: Rheumatoid Arthritis is a symmetric, inflammatory polyarthritis characterized by erosion of cartilage and bone leading to joint destruction. Apart from the articular target, nonarticular tissues can also be affected leading to severe systemic disease.


Objectives: We aim to evaluate the incidence of interstitial lung disease in Rheumatoid arthritis, the association and severity in hospitalized patients.


Methods: We analyzed data of patients 18 years and above hospitalized with a primary or secondary diagnosis of Rheumatoid Arthritis admitted in United States hospitals from 2017 to 2021 using the National Inpatient Sample (NIS) data.


Results: The mean age of patients with rheumatoid arthritis was 67.8 years, and the mean length of hospital stay was 5.2 days. The rheumatoid arthritis patients were older than non-rheumatoid patients admitted to the hospitals (67.8 vs. 57.9 years, p<0.001). The rheumatoid arthritis patients were predominantly females (73.8%). Compared with other patients admitted to the hospital, the rheumatoid arthritis patients were more likely to have interstitial lung disease (3.4% vs. 0.7%, p<0.001). In the bivariate analysis of patients with rheumatoid arthritis, patients with interstitial lung disease were older than those without (71.08 vs. 67.66 years, p<0.001). Males were more likely to have interstitial lung disease compared to females (4% vs. 3.2%, p<0.001). The odds of having interstitial lung disease increased with age from 1.6% in those between 18 and 44 years to 4.3% in those 75 years and above. Compared to other racial groups, Whites were less likely to have interstitial lung disease (3.2% vs. 4.1%, p<0.001). Patients with interstitial lung disease were more likely to die during hospital admission (7.6% vs. 3.3%, p<0.001). They were also more likely to have pulmonary hypertension (11.7% vs. 2.9%, p<0.001), rheumatoid vasculitis (5.6% vs. 3.4%, p=0.007), rheumatoid polyneuropathy (5.7% vs. 3.4%, p=0.005), and rheumatoid nodule (8% vs. 3.4%, p<0.001). Furthermore, patients with interstitial lung disease were more likely to have heart failure (5.3% vs. 2.8%, p<0.001), atrial fibrillation (4.3% vs. 3.2%, p<0.001), pleural effusion (4.2% vs. 3.4%, p<0.001) and pneumothorax (9.9% vs. 3.4%, p<0.001). In the multivariate analysis of patients with Rheumatoid arthritis, interstitial lung disease was associated with increased odds of in-hospital mortality (OR 1.88, 95% CI 1.76-2.01, p<0.001), length of stay (OR 1.01, 95% CI 1.009-1.012, p<0.001), pulmonary hypertension (OR 3.66, 95% CI 3.51-3.81, p<0.001), heart failure (OR 1.34, 95% CI 1.29-1.39, p<0.001), pneumothorax (OR 2.38, 95% CI 1.99-2.84, p<0.001), rheumatoid vasculitis (OR 1.75, 95% CI 1.19-2.48, p=0.005), rheumatoid nodule (OR 2.36, 95% CI 1.64-3.39, p<0.001), and rheumatoid polyneuropathy (OR 1.73, 95% CI 1.19-2.52, p=0.004). The odds of interstitial lung disease increased with age, with the highest odds in patients 75 years and above (OR 2.42, 95% CI 2.21-2.64, p<0.001).


Conclusion: Our analysis of the largest hospital database in the USA demonstrates interstitial lung disease in hospitalized Rheumatoid Arthritis patients leads to increased complications and all cause mortality. A slightly different treatment approach targeting non-articular organ systems, early in disease onset, in Rheumatoid arthritis could show improvement in the overall disease outcome.


REFERENCES: NIL.


Acknowledgements: NIL.


Disclosure of Interests: None declared.

© The Authors 2025. This abstract is an open access article published in Annals of Rheumatic Diseases under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ ). Neither EULAR nor the publisher make any representation as to the accuracy of the content. The authors are solely responsible for the content in their abstract including accuracy of the facts, statements, results, conclusion, citing resources etc.


DOI: annrheumdis-2025-eular.A1571
Keywords: Autoantibodies, Lungs, Epidemiology, Quality of life, Diversity, Equity, And Inclusion (DEI)
Citation: , volume 84, supplement 1, year 2025, page 1434
Session: Poster View VIII (Poster View)