Background: Familial Mediterranean fever is the most common inherited autoinflammatory syndrome. If it is not diagnosed or treated properly, patients may develop AA amyloidosis which is the main cause ‎ of mortality. Dyslipidemia can coexist with auto inflammatory disorders and is one of the main risk factors for ‎ the development of future cardiovascular events. ‎ Recently, fibrinogen to albumin ratio (FAR) has been introduced as new concept of an inflammation-related index.

Objectives: To investigate lipid profiles and atherogenic indices and to explore the clinical value of Fibrinogen to Albumin Ratio (FAR) in FMF juvenile patients.

Methods: This case control study included 45 FMF children up to 16 years old. The diagnosis of the FMF patients was based on EUROFEVER/PRINTO clinical and genetic criteria. In this study we measured fibrinogen to albumin ratio and atherogenic indices (atherogenic index of plasma (AIP), atherogenic coefficient (AC), Castelli risk indices 1,2 (CRI-1,2)). Disease activity was assessed by physical examination and laboratory tests (serum amyloid A, CRP).

Results: There were statistically significant higher levels of triglycerides, LDL, and total cholesterol in FMF patients than control group. There was statistically significant lower level of HDL among cases than control group. There were statistically significant higher mean CRI-1, CRI-II, atherogenic index of plasma, atherogenic coefficient and FAR among cases than control group.

Conclusions: FAR is a simple, inexpensive, easily obtained indicator which can be used for reflecting inflammation in FMF. Atherogenic indices can be used as a more accurate marker of hyperlipidemia than lipid profile. FMF can lead to dyslipidemia and subsequent atherosclerosis and CVDs.

REFERENCES: NIL.

Acknowledgments: NIL.

Disclosure of Interests: None declared.