Background: Patients with autoimmune inflammatory rheumatic diseases are susceptible to infections. This could be attributed to theimmunosuppressive effect of the underlying condition or the use of immunomodulatory medications. According to the Department of Health guidelines inthe UK and the European League Against Rheumatism (EULAR), patients who are immunosuppressed should be vaccinated against influenza and pneumococcal infection, as well as COVID-19 infection.

Objectives: Our aim was to explore the Pneumococcal, Influenza and COVID-19 vaccination uptake of our patients with different autoimmune inflammatory rheumatological conditions. In addition, to assess the side effects profile and the status of their underlying rheumatological diseases following COVID-19 vaccination.

Methods: We undertook a prospective audit of consecutive patients with regards to their vaccination update for influenza, pneumococcus, and COVID-19, utilizing a standard questionnaire and compared the results to our 2017 data.

Results: Some 81% of patients received the influenza vaccination (compared to 47% in 2017) representing a 172% improvement, p<0.001. Some 53% received the pneumococcus vaccination compared to 28% in 2017, indicating a 185% improvement, p=0.003. With regards to COVID-19 vaccination, 98/101(97%) of eligible patients received at least one dose and 66% received two doses. 47% received Astra Zeneca, 52% Pfizer and 1% unsure. 46% of patients mentioned, no one specifically discussed the COVID vaccine with them - got information via SMS/ from media, However, 37% of patients were informed by GP Doctor/ Nurse, 14% from the person giving the vaccine, and 7% from specialist hospital doctor. Safety concerns were indicated by all 3 patients who deferred vaccination.

Most side-effects were observed following the first dose (74 patients) vs. the second dose (13 patients) and were mainly mild (66%), but also moderate (19%) and severe (15%). The sore arm was the commonest side-effect, whilst the majority of side-effects resolved within two days. Crucially, 28% reported a flare of the rheumatological condition following the vaccination. No patients receiving at least one dose were diagnosed with COVID-19 infection subsequently.

Conclusion: Vaccination rates for influenza and pneumococcus have improved substantially since 2017, although the population with rheumatic diseases still has low uptake in pneumococcal vaccination. The COVID-19 vaccination uptake has been extremely high in this cohort.

Disclosure of Interests: None declared