Background: Gout the most common microcrystalline rheumatism is influenced by various epidemiological and clinical factors that may vary between genders.

Objectives: This study compares the epidemiological, clinical characteristics, and comorbidities associated with gout in men and women.

Methods: Retrospective study (2012–2024) including patients with gout.

Results: 147 patients were included in the study, comprising 92 males (62.6%) and 55 females (37.4%). The mean age was 60.85 ± 13 years for males and 64.9 ± 11 years for females. Smoking was reported in 13.04% of males and 1.8% of females. Diabetes was more frequent in females (38.18%) compared to males (18.47%), as were hypertension (58.18% vs. 34.7%), dyslipidemia (21.8% in females vs. 18.4% in males), and metabolic syndrome (34.5% in females vs. 22.8% in males). Renal involvement was noted in 31.6% of females and 23.9% of males, while renal stones were present in 8.3% of females and 7.2% of males. Fever was observed in 6% of females and 13.2% of males. The mean pain visual analog scale (VAS) score was 49.89 ± 17 in males versus 41.09 ± 18 in females (p = 0.005). Monoarticular involvement was more frequent in females (74.5%) than in males (67.3%), whereas polyarticular forms were observed in 25.4% of females and 32.6% of males. Tophi were more common in males (10.8%) than in females (3.6%, p = 0.021). The mean serum uric acid level was 77.28 ± 24 mg/L in females and 81.23 ± 24 mg/L in males. A significant inflammatory syndrome was more frequent in males (p = 0.003), with a mean CRP level of 71.20 ± 19 mg/L in males versus 46.77 ± 21 mg/L in females. Renal function was more impaired in females, with an average creatinine clearance of 36.2 ± 21 mL/min compared to 51.4 ± 22 mL/min in males (p = 0.003). Radiographic gouty arthropathy was detected in 18.9% of females and 34.5% of males. Joint aspiration revealed microcrystals in 10.9% of females and 15.21% of males. Chronic gout was diagnosed in 29.3% of females and 35.4% of males.

Conclusion: Women exhibited more metabolic comorbidities and severe renal impairment, while men had more pronounced inflammatory syndromes, tophi, and gouty arthropathy.

REFERENCES: NIL.

Acknowledgements: NIL.

Disclosure of Interests: None declared.

© The Authors 2025. This abstract is an open access article published in Annals of Rheumatic Diseases under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ ). Neither EULAR nor the publisher make any representation as to the accuracy of the content. The authors are solely responsible for the content in their abstract including accuracy of the facts, statements, results, conclusion, citing resources etc.